Tag Archives: Coriolus versicolor

In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs.

Y Dong, MM Yang, CY Kwan.

Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong.

Coriolus versicolor polysaccharide peptide (CVP) and the bis-benzylisoquinoline alkaloids, tetrandrine (TET) and berbamine (BER), the active ingredients isolated from Chinese medicinal herbs known to possess antitumor activities, concentration-dependently inhibited the proliferation of human leukemic HL-60 cells. CVP did not affect the growth of normal human peripheral blood lymphocytes (PBL), whereas TET elicited concentration-dependent cytotoxic effects. Morphological observation and DNA analysis revealed that CVP elicited no effect on the morphological features of HL-60 cells and did not cause DNA fragmentation, but TET and BER caused cell shrinkage with the formation of apoptotic bodies, and showed clear evidence of DNA fragmentation. These findings indicate that TET and BER, but not CVP, inhibited the proliferation of HL-60 cells via induction of apoptosis.

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CRISTINA FERRARE TO HOST NEW INFOMERCIAL

Irvine, Californa (December 6, 2010)  inLife LLC, distributors of science-based Health & Wellness products today announced that a new infomercial hosted by TV personality Cristina Ferrare will begin airing December 28 and will feature inLife’s new ground-breaking immune building product, inForce. “We are very excited to be working with Cristina Ferrare as our infomercial host”, stated Craig Youngblood, CEO and Founder of inLife. Worldwide there have been over 400 animal and human studies on inForce’s main ingredients PSK & PSP, extracts of the Coriolus versicolor mushroom, which have also been the subjects of over a dozen placebo-based human trials conducted in the west.

About Cristina Ferrare

Cristina is a talented television personality and bestselling author on women’s health issues, style and healthy family living. Cristina is also the star of her own cooking show “A Big Bowl of Love” on the new Oprah Winfrey Network. The show will air 3:30 PM (M-F). Cristina states that “inForce is the best all- natural product I’ve found to keep me and my family safer by boosting our bodies’ immune system.”

About Coriolus Versicolor

The Coriolus versicolor mushroom is one of the most widely studied immune building supplements. Worldwide, there have been over 400 animal and human studies on PSK & PSP, both polysaccharide extracts of the Coriolus versicolor mushroom with over a dozen placebo-based human trials conducted in the west. Traditionally, the Coriolus versicolor mushroom (known as Yun-zhi or cloud mushroom in China) has been used in China for several thousand years because of its immune boosting capabilities. In the 1980s, Dr. Yang conducted further studies and was able to isolate a much more potent strain using a different, alcohol-based extraction process. The result was Polysaccharopeptide or PSP. In the United States, top-ranked hospital and research institutes have reported that Coriolus versicolor helps boost the body’s immune system with limited side effects and safety of daily oral doses for extended periods of time. In addition, Coriolus versicolor and its potential positive effects has been studied very closely by M.D. Anderson, University of Texas, Loma Linda University, Beth Israel Deaconess Medical Center (a teaching hospital of Harvard Medical School) , The University of San Diego, Sloan-Kettering Center (New York), and Bastyr University (Kenmore, Washington), just to name a few.

inLife Immune Builder with PSP and PSK

inLife offers Coriolus versicolor as a Daily Dietary Supplement in capsule form to help maintain and stimulate the body’s immune system. Coriolus versicolor and its high-potency extracts, PSK and PSP are among the most widely studied supplements for their immune building properties and the incredibly positive results of these studies are compelling. InForce Immune Builder is a proprietary blend of both Polysaccharide-K (PSK) and Polysaccharopeptide (PSP). Both offer valuable immune building assistance and can be taken on a daily basis. The products are bottled in the United States in an FDA registered bottling facility that is CGMP compliant (Current Good Manufacturing Practices).

About inLife, LLC

Founded in 2007, inLife has been very successful in bringing to market products with efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and on the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

Click here to download this press release.

[Studies on antitumor activities of Basidiomycetes-antitumor activity of polysaccharides and sex factors]

[Article in Japanese]

Ito H, Naruse S, Sugiura M.

Abstract

We have already reported antitumor activities of fungal and bacterial polysaccharides on mice. In the present experiment, the influence of the sex on antitumor effects on such material from Grifola umbellata, Coriolus versicolor Fries or Sargassum thumbergii and the immunity of mice against tumor were investigated. The growth velocities of Sarcoma 180, Ehrlich solid carcinoma, Pulmonary tumor 7423 and MF-sarcoma bearing mice both without treatment and those treated with polysaccharides were more rapid in males than in females. The regression rates in mice with the above tumors were higher in females than in males. However, a few DS Mie mice with Sarcoma 180 and A/Jax Mie mice with Ehrlich solid carcinoma regressed spontaneously. The growth velocity of Shionogi carcinoma 42 was not influenced by the sex. On other hand, both males and females which had experienced a regression of ascites tumor after the administration of polysaccharides rejected the re-implanted Ehrlich ascites carcinoma, Sarcoma 180, NF-sarcomma and Shionogi carcinoma 42. These results suggest that a strong ehancement of immune response occurs in the tumor implanted in the host animal by the administration of polysacchrides. The combination of X-ray irradiation Ehrlich ascites cells and polysacchrides strengthens the antitumor effect of NF-sarcoma and Shionogi carcinoma 42. Peritoneal exudate cells and lymphocytes were compared between the male and female mice after being treated with ATSO and P.GU-1. Such cells were present to a much greater extent in females.

PMID: 986353 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/986353

Requirement for a growth substrate during lignin decomposition by two wood-rotting fungi.

Kirk TK, Connors WJ, Zeikus JG.

Forest Products Laboratory, Forest Service, U. S. Department of Agriculture, Madison, Wisconsin 53705.

Abstract

Decomposition of C-labeled lignin to CO(2) by the lignin-decomposing fungi Phanerochaete chrysosporium and Coriolus versicolor required a growth substrate such as cellulose or glucose. Growth with lignin as sole carbon addition to an otherwise complete medium was negligible.

PMID: 16345166 [PubMed]PMCID: PMC170029

http://www.ncbi.nlm.nih.gov/pubmed/16345166

Blastoid transformation of human lymphocytes cultured with protein-bound polysaccharide preparation, PS-K, in vitro.

Ohno R, Yokomaku S, Wakayama K, Sugiura S, Yamada K.

Abstract

The protein-bound polysaccharide preparation, PS-K, isolated from a mushroom, Coriolus versicolor, was found to stimulate human lymphocytes and induce them into blastogenesis in vitro. This stimulatory effect seemed to be nonspecific since lymphocytes from cord blood of newborn babies were also stimulated by PS-K. The highest lymphocyte blastogenesis by PS-K was observed after 5 days in culture.

PMID: 1017585 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/1017585