Tag Archives: coriolus versicolor psp

The use of mushroom glucans and proteoglycans in cancer treatment.

Kidd PM.

Abstract

Immunoceuticals can be considered as substances having immunotherapeutic efficacy when taken orally. More than 50 mushroom species have yielded potential immunoceuticals that exhibit anticancer activity in vitro or in animal models and of these, six have been investigated in human cancers. All are non-toxic and very well tolerated. Lentinan and schizophyllan have little oral activity. Active Hexose Correlated Compound (AHCC) is poorly defined but has shown early clinical promise. Maitake D-Fraction has limited proof of clinical efficacy to date, but controlled research is underway. Two proteoglycans from Coriolus versicolor – PSK (Polysaccharide-K) and PSP (Polysaccharide-Peptide – have demonstrated the most promise. In Japanese trials since 1970, PSK significantly extended survival at five years or beyond in cancers of the stomach, colon-rectum, esophagus, nasopharynx, and lung (non-small cell types), and in a HLA B40-positive breast cancer subset. PSP was subjected to Phase II and Phase III trials in China. In double-blind trials, PSP significantly extended five-year survival in esophageal cancer. PSP significantly improved quality of life, provided substantial pain relief, and enhanced immune status in 70-97 percent of patients with cancers of the stomach, esophagus, lung, ovary, and cervix. PSK and PSP boosted immune cell production, ameliorated chemotherapy symptoms, and enhanced tumor infiltration by dendritic and cytotoxic T-cells. Their extremely high tolerability, proven benefits to survival and quality of life, and compatibility with chemotherapy and radiation therapy makes them well suited for cancer management regimens.

PMID: 10696116 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/10696116

Immunomodulation and anti-cancer activity of polysaccharide-protein complexes.

Ooi VE, Liu F.

Department of Biology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

Abstract

In the last three decades, numerous polysaccharides and polysaccharide-protein complexes have been isolated from mushrooms and used as a source of therapeutic agents. The most promising biopharmacological activities of these biopolymers are their immunomodulation and anti-cancer effects. They are mainly present as glucans with different types of glycosidic linkages such as (1–>3), (1–>6)-beta-glucans and (1–>3)-alpha-glucans, and as true herteroglycans, while others mostly bind to protein residues as polysaccharide-protein complexes. Three antitumor mushroom polysaccharides, i.e. lentinan, schizophyllan and protein-bound polysaccharide (PSK, Krestin), isolated respectively, from Lentinus edodes, Schizophyllum commune and Coriolus versicolor, have become large market items in Japan. Lentinan and schizophyllan are pure beta-glucans, whereas PSK is a protein-bound beta-glucan. A polysaccharide peptide (PSP), isolated from a strain of Coriolus versicolor in China, has also been widely used as an anti-cancer and immunomodulatory agent. Although the mechansim of their antitumor action is still not completely clear, these polysaccharides and polysaccharide-protein complexes are suggested to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers. Potentiation of the host defense system may result in the activation of many kinds of immune cells that are vitally important for the maintenance of homeostasis. Polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of vaious immunomodulatory cytokines and cytokine receptors. Some interesting studies focus on investigation of the relationship between their structure and antitumor activity, elucidation of their antitumor mechanism at the molecular level, and improvement of their various biological activities by chemical modifications.

PMID: 10702635 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/10702635

World Renowned Chiropractor, Dr. Jim Sigafoose, Joins inLife LLC to Promote Their New Immune Boosting Product inForce Immune Builder to the Chiropractic Community

Irvine, California (Oct 04, 2010) inLife LLC distributors of science-based Health & Wellness products today announced that Dr. Jim Sigafoose is joining inLife LLC to promote the immunological benefits of their new product, inForce. Dr. Sigafoose has become a great believer of inForce’s main ingredient Coriolus versicolor after studying all the scientific data and seeing firsthand those whose lives have already benefitted.

Dr James M. Sigafoose is recognized worldwide for his inspirational Chiropractic philosophy and motivational teaching. A Featured Speaker at Dynamic Essentials (DE) for over 45 years and a Team Speaker at Parker Seminars for the past 15 years, Dr. Sigafoose is considered one of the top speakers in the Chiropractic profession and a recognized leader in the world of natural healing. Dr Sigafoose has spoken internationally in countries including: Japan, Australia and Spain. He has been honored as Chiropractor of the Year numerous times by various Chiropractic colleges and organizations.

About Coriolus Versicolor

The Coriolus Versicolor mushroom is one of the most widely studied supplements for its immune building properties. Worldwide, there have been over 400 animal and human studies on Coriolus versicolor with over a dozen placebo-based human trials conducted in the west. Traditionally, the Coriolus versicolor mushroom (known as Yun-zhi or cloud mushroom in China) has been used in China for several thousand years because of its immune boosting capabilities. In the 1980s, Dr. Yang conducted further studies and was able to isolate a much more potent strain using a different, alcohol-based extraction process. The result was Polysaccharopeptide or PSP. In the United States, top-ranked hospital and research institutes have reported that Coriolus versicolor helps boost the body’s immune systems with limited side effects and safety of daily oral doses for extended periods of time. In addition, Coriolus versicolor and its potential positive effects has been studied very closely by M.D. Anderson, University of Texas, Loma Linda University, Beth Israel Deaconess Medical Center (a teaching hospital of Harvard Medical School) , The University of San Diego, Sloan-Kettering Center (New York), and Bastyr University (Kenmore, Washington) just to name a few.

inLife Immune Builder with PSP and PSK

inLife offers Coriolus versicolor as a Daily Dietary Supplement in capsule form to help maintain and stimulate the body’s immune system. Coriolus versicolor and its high-potency extracts, PSK and PSP are among the most widely studied supplements for their immune building properties. One would be hard-pressed to find another immune boosting product that has had more research completed or positive comments associated with it. The amount of worldwide comments and studies is compelling. InForce Immune Builder is a proprietary blend of both Polysaccharide-K (PSK) and Polysaccharopeptide (PSP). Both offer much needed immune building assistance and they can be taken on a daily basis. The products are bottled in the United States in an FDA registered bottling facility that is CGMP compliant (Current Good Manufacturing Practices).

About inLife LLC

Founded in 2007, inLife has been very successful in bringing to market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

# # #

Founded in 2007, inLife has been very successful in bringing to market products that have efficacies that are soundly based on scientific research. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

Click here to download this press release.

PSP Inventor Dr. Yang Gives inLife Exclusive Distribution Rights for Coriolus versicolor PSP

Irvine, California (September 22, 2010) inLife, LLC, distributors of science-based Health & Wellness products today announced that Professor Q.Y. Yang, inventor of the Coriolus versicolor mushroom Polysaccharopeptide (PSP, also commonly called Polysaccharide-peptide) extract, has given to inLife, LLC the exclusive distribution rights wherever inLife distributes its products. Dr. Yang is recognized as the world’s foremost expert on Coriolus versicolor research. He is currently the director of the Research Institute of Microbiology & Immunology of Shanghai Teachers University, where he invented the technique of submerged cultivation of mycelia of mushrooms.

“inLife is thrilled to have learned today that Dr. Yang has entrusted inLife with the honor of distributing his Coriolus versicolor PSP. There are literally today millions of people who can benefit from Dr. Yang’s PSP and we are very excited that inLife will be the messenger to enlighten so many about its efficacies and properties” stated Craig Youngblood, President and CEO of inLife, LLC.

Dr. Yang is responsible for identifying and isolating the most effective COV-1 strain from over 100 different strains of Coriolus versicolor. In recognition of his invention of PSP and also his outstanding achievements in traditional Chinese medicine, Professor Yang has been recognized with many international honors. Dr. Yang has also received a patent for his discovery of PSP extraction process.

About Coriolus versicolor

The Coriolus versicolor mushroom is one of the most widely studied supplements for its immune building properties. Worldwide, there have been over 400 animal and human studies on Coriolus versicolor with over a dozen placebo-based human trials conducted in the west. Traditionally, the Coriolus versicolor mushroom (known as Yun-zhi or cloud mushroom in China) has been used in China for several thousand years because of its immune boosting capabilities. In the 1980s, Dr. Yang conducted further studies and was able to isolate a much more potent strain using a different, alcohol-based extraction process. The result was Polysaccharopeptide or PSP. In the United States, top-ranked hospital and research institutes have reported that Coriolus versicolor helps boost the body’s immune system with limited side effects and safety of daily oral doses for extended periods of time. In addition, Coriolus versicolor and its potential positive effects has been studied very closely by M.D. Anderson, University of Texas, Loma Linda University, Beth Israel Deaconess Medical Center (a teaching hospital of Harvard Medical School) , The University of San Diego, Sloan-Kettering Center (New York), and Bastyr University (Kenmore, Washington) just to name a few.

inLife Immune Builder with PSP and PSK

inLife offers Coriolus versicolor as a Daily Dietary Supplement in capsule form to help maintain and stimulate the body’s immune system. Coriolus versicolor and its high-potency extracts, PSK and PSP are among the most widely studied supplements for their immune building properties. One would be hard-pressed to find another immune boosting product that has had more research completed or positive comments associated with it. The amount of worldwide comments and studies is compelling. InForce Immune Builder is a proprietary blend of both Polysaccharide-K (PSK) and Polysaccharopeptide (PSP). Both offer much needed immune building assistance and they can be taken on a daily basis. The products are bottled in the United States in an FDA registered bottling facility that is CGMP compliant (Current Good Manufacturing Practices).

About inLife LLC

Founded in 2007, inLife has been very successful in bringing to market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

# # #

About inLife, LLC Founded in 2007, inLife has been very successful in bringing to market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

Click here to download this press release.

Polysaccharide peptides from COV-1 strain of Coriolus versicolor induce hyperalgesia via inflammatory mediator release in the mouse.

Polysaccharide peptide (PSP), isolated from Coriolus versicolor COV-1, has been widely used as an adjunct to cancer chemotherapy and as an immuno-stimulator in China. In this study, the anti-nociceptive effects of PSP were investigated in two different pain models in the mouse. In the acetic acid-induced writhing model, initial studies showed that PSP decreased the number of acetic acid-induced writhing by 92.9%, which, by definition, would constitute an analgesic effect. However, further studies showed that PSP itself induced a dose-dependent writhing response. Studies on inflammatory mediator release showed that PSP increased the release of prostaglandin E2, tumor necrosis factor-alpha, interleukin-1beta, and histamine in mouse peritoneal macrophages and mast cells both in vitro and in vivo. The role of inflammatory mediator release in PSP-induced writhing was confirmed when diclofenac and dexamethasone decreased the number of writhing responses by 54% and 58.5%, respectively. Diphenhydramine totally inhibited the PSP-induced writhhttps://mushroomstudies.co/wp-admin/post-new.phping. In the hot-plate test, PSP dose-dependently shortened the hind paw withdrawal latency, indicative of a hyperalgesic effect. The hyperalgesic effect was reduced by pretreatment with the anti-inflammatory drugs. In conclusion, the PSP-induced hyperalgesia was related to activation of peritoneal resident cells and an increase in the release of inflammatory mediators.

PMID: 16310221 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/16310221

Dr. Yang, Inventor of Coriolus Versicolor PSP extract, Joins inLife as Medical Advisor

Irvine, California (September 15, 2010) inLife, LLC distributors of science-based Health & Wellness products today announced that Professor Q.Y. Yang, inventor of Coriolus versicolor mushroom Polysaccharopeptide (PSP, also commonly called Polysaccharide-peptide) extract, will be on inLife’s Board as Medical Advisor. Dr. Yang is recognized as the world’s foremost expert on Coriolus versicolor research. He is currently the director of the Research Institute of Microbiology & Immunology of Shanghai Teachers University, where he invented the technique of submerged cultivation of mycelia of mushrooms. Dr. Yang is responsible for identifying and isolating the most effective COV-1 strain from over 100 different strains of Coriolus versicolor. In recognition of his invention of PSP and also his outstanding achievements in traditional Chinese medicine, Professor Yang has been recognized with many international honors. Dr. Yang has also received a patent for his discovery of PSP extraction process.

About Coriolus Versicolor

The Coriolus Versicolor mushroom is one of the most widely studied supplements for its immune building properties. Worldwide, there have been over 400 animal and human studies on Coriolus versicolor with over a dozen placebo-based human trials conducted in the west. Traditionally, the Coriolus versicolor mushroom (known as Yun-zhi or cloud mushroom in China) has been used in China for several thousand years because of its immune boosting capabilities. In the 1980s, Dr. Yang conducted further studies and was able to isolate a much more potent strain using a different, alcohol-based extraction process. The result was Polysaccharopeptide or PSP. In the United States, top-ranked hospital and research institutes have reported that Coriolus versicolor helps boost the body’s immune systems with limited side effects and safety of daily oral doses for extended periods of time. In addition, Coriolus versicolor and its potential positive effects has been studied very closely by M.D. Anderson, University of Texas, Loma Linda University, Beth Israel Deaconess Medical Center (a teaching hospital of Harvard Medical School) , The University of San Diego, Sloan-Kettering Center (New York), and Bastyr University (Kenmore, Washington) just to name a few.

inLife Immune Builder with PSP and PSK

inLife offers Coriolus versicolor as a Daily Dietary Supplement in capsule form to help maintain and stimulate the body’s immune system. Coriolus versicolor and its high-potency extracts, PSK and PSP are among the most widely studied supplements for their immune building properties. One would be hard-pressed to find another immune boosting product that has had more research completed or positive comments associated with it. The amount of worldwide comments and studies is compelling. InForce Immune Builder is a proprietary blend of both Polysaccharide-K (PSK) and Polysaccharopeptide (PSP). Both offer much needed immune building assistance and they can be taken on a daily basis. The products are bottled in the United States in an FDA registered bottling facility that is CGMP compliant (Current Good Manufacturing Practices).

About inLife, LLC

Founded in 2007, inLife has been very successful in bringing to market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

# # #

Founded in 2007, inLife has been very successful in bringing to market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

Click here to download this press release.

Effects of polysaccharide peptides from COV-1 strain of Coriolus versicolor on glutathione and glutathione-related enzymes in the mouse.

Yeung JH, Or PM.

Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China. johnyeung@cuhk.edu.hk

Abstract

The effects of polysaccharide peptide (PSP), an immunomodulator isolated from Coriolus versicolor COV-1, on glutathione (GSH) and GSH-related enzymes was investigated in C57 mouse. Administration of PSP (1-4 micromole/kg, i.p.) produced a transient, dose-dependent depletion (10-37%) of hepatic GSH, with no effect on serum glutamic-pyruvic transaminase (SGPT) activity. Blood GSH was depleted (6-25%) at 3 h, followed by a rebound increase above the control GSH level (20%) at 18 h. The GSSG/GSH ratio, a measure of oxidative stress, was increased 3 h after PSP treatment but returned to normal levels at 24 h. Sub-chronic treatment of PSP (1-4 micromole/kg/day, i.p.) for seven days did not produce any significant changes in hepatic GSH levels and the GSSG/GSH ratio when measured 24 h after the final dose of PSP. PSP had little effect on glutathione transferase (GST), glutathione reductase (GSSG reductase) and glutathione peroxidase (GPX) activities in the liver. However, a dose-dependent increase in blood GPX activity (30-48%) was observed at 3h, which coincided with the increase in the GSSG/GSH ratio. The increase in blood GPX activity may be a responsive measure to deal with the transient oxidative stress induced by PSP treatment. The results showed that PSP only caused a transient perturbation on hepatic glutathione without affecting the GSH-related enzymes such as GST, GSSG reductase and GPX. The observed changes in blood GSH simply reflected the intra-organ translocation of glutathione, as the glutathione-related enzymes were not significantly affected by PSP treatment.

PMID: 17240508 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/17240508

Introducing inForce Immune Builder

Irvine, California (September 7, 2010) inLife, LLC, distributors of science-based Health & Wellness products, today introduced inForce Immune Builder, a new product that clinical research shows helps stimulate the body’s immune system. inForce’s main ingredient, the Coriolus versicolor mushroom mycelia extract, is one of the most widely studied supplements for its immune building properties and is now available to the public and the direct-selling industry. Worldwide, there have been over 400 animal and human studies on Coriolus versicolor, with over a dozen placebo-based human trials conducted in the west.

inLife Immune Builder with PSP and PSK
inLife offers Coriolus versicolor as a Daily Dietary Supplement in vegan capsule form to help maintain and stimulate the body’s immune system. Coriolus versicolor, PSK and PSP are among the most widely studied supplements for their immune building properties. One would be hard pressed to find another immune boosting product that has had more research completed or positive comments associated with it. The amount of worldwide comments and studies is compelling. inForce Immune Builder is a proprietary blend of both Polysaccharide-K (PSK) and Polysaccharide Peptide (PSP). Both offer much-needed immune building assistance and they can be taken on a daily basis. The products are bottled in the United States in an FDA-registered bottling facility that is cGMP compliant (Current Good Manufacturing Practices).

Hospital and Research Institutes Report on Coriolus Versicolor
In the United States, top-ranked hospital and research institutes have reported that “Coriolus versicolor, PSK and PSP help boost the body’s immune system with limited side effects and safety of daily oral doses for extended periods of time.” In addition, Coriolus versicolor and its potential positive effects has been studied very closely by M.D. Anderson, University of Texas, Loma Linda University, Beth Israel Deaconess Medical Center (a teaching hospital of Harvard Medical School) , The University of San Diego, Sloan-Kettering Center (New York), and Bastyr University (Kenmore, Washington), just to name a few.

About inLife, LLC
Founded in 2007, inLife has been very successful in bringing to the market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

# # #

Founded in 2007, inLife has been very successful in bringing to the market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain.

Click here to download this press release.

Coriolus Versicolor is Potent Mushroom for Fighting Cancer and Autoimmune Diseases – By: Barbara L. Minton, citizen journalist

(NaturalNews – January 28, 2009) For thousands of years Chinese medicine has prized the mushroom for its energizing and healing properties. Chinese legend is filled with stories of those who discovered the 1,000 year old mushroom and became immortal. In the West, acceptance is based less on tradition and more on the results of the scientific method. Researchers have been busy scientifically documenting what Chinese tradition dictates, that mushrooms are some of the most potent medicines on the plant. Recent research findings have shown the Coriolus versicolor mushroom stands out above the rest for regulating the immune system.

Coriolus versicolor found to be effective against cancer and human papillomavirus

Researchers at the Sloan-Kettering Cancer Center in New York tested several botanicals for their immune enhancing activity using a subcutaneous immunization model of cell surface carbohydrate expression in cancer cells in a study published in September, 2008 Vaccine. They found Coriolus versicolor to display consistent and significant immune enhancement activity superior to all other coumpounds tested. The superiority of Coriolus to yeast beta-glucan, maitake, turmeric, echinacea, and preparation H-48 from Honso USA, was described as surprising. Although the exhibited levels of immune enhancing ability of astragalus was also impressive, it was surpassed by that of Coriolus.

The March, 2008 BMC Cancer reports Coriolus versicolor has shown anticancer activity with positive results in the treatment of gastric, esophageal, colorectal, breast and lung cancers. The efficacy of its protein-bound polysaccharide as an immunomodulator is credited. This activity was independent of its previously described immunomodulatory effect on NK cells.

The journal Cancer Immunology and Immunotherapy reports double blind trials on 111 patients with colorectal cancer, using Coriolus versicolor. Although traditional medicine offers little help for colon cancer patients, Coriolus showed a remarkable enhancement of the patient’s white blood cells, even in advanced colon cancer cases. The white cells greatly increased natural chemotactic motion and phagocytosis, the ability to scavenge toxins and kill pathogens. Coriolus was also used with patients as a helpful maintenance therapy following cancer surgery.

The results of a year long clinical trial examining the effects of mushroom supplementation in patients with Human Papillomavirus (HPV) were so impressive they were presented in 2008 at the 20th European Congress of Obstetrics and Gynocology. Dr. Silva Couto and his research team found that Coriolus versicolor supplementation over the period of one year substantially increased regression of dysplasia and induced clearance of the high-risk subtypes of the HPV responsible for cervical cancer. Coriolus supplementation demonstrated a 72 percent regression rate in lesions compared to 47.5 percent without supplementation, and a 90 percent regression rate in the high risk HPV virus sub-types compared to 8.5 percent without.

After using the supplement for one year, 72.5 percent of recipients reverted to normal cytology compared with only 47.5 percent of the control group. Coriolus supplementation produced a 90 percent regression rate in the high risk HPV virus sub-tupes compared to an 8.5 percent regression without supplementation.

It is also likely that Coriolus versicolor would be beneficial in high-grade squamous intraepithelial lesion (HSIL), a precancerous condition in which the cells of the uterine cervix are moderately or severely abnormal. The lead physician of the study noted that the optimal supplementation period may be as short as six months.

Coriolus versicolor modulates autoimmune diseases

T cells belong to a group of while blood cells known as lymphocytes, and play a central role in cell-mediated immunity. The activation of T helper (Th) cell subsets also plays an important role in immunity. Uncontrolled Th responses lead to autoimmune and inflammatory diseases. The identification of agents that modulate these helper cells is essential for controlling autoimmune diseases. A study from the November, 2008 Journal of Pharmacy and Pharmacology, reported that polysaccharopeptide (PSP) from Coriolus versicolor exhibited the ability to control aberrant T lymphocyte activation through ciclosporin-like activity. PSP alone suppress production of activated T cells.

What makes Coriolus versicolor special?

Coriolus versicolor, also referred to as the turkey-tail mushroom, contains large quantities of Beta-glucans that act to stimulate the immune system. Coriolus can dramatically regenerate and rejuvenate the body. Its most active medicinal components are biological response modifiers called protein-bound polysaccharides. These polysaccharides are known as Krestin or PSK in Japan, and as Yun zhi, or PSP in China. There have been reports of cases of Bell’s palsy clearing up with use of Coriolus for just a few days. Others have found it effective against bronchitis.

Other studies have shown that Coriolus can double the number of natural killer cells after only 8 weeks of treatment. Coriolus has also been found to help patients with chronic fatigue syndrome and may be an effective treatment for Lyme disease.

More research documents the anti-tumor benefits of Coriolus

Japanese researchers screened 200 of the best phytochemicals (plant extracts) known for anti-tumor activity. Coriolus versicolor was designated as exhibiting the greatest amount of anti-tumor activity. In another Japanese study, 185 people with lung cancer at different stages were given radiation. Doctors found those who also took Coriolus showed the best tumor shrinkage and the best survival rate. Another study involving stomach cancer patients produced similar results. Those who received Coriolus survived significantly longer, felt better and had fewer side effects.

Coriolus is first line defense against infection

Coriolus is a good centerpiece for your natural medicine chest, even if you are currently the picture of health. When any type of infection strikes, you will be ready. Coriolus can be used to target any infected organ, gland or tissue. Its immune enhancing properties provide an increased response to deal effectively with infections, and do this without over stimulating the immune system.

Sources:

Clinical Trial Results Show Proof of Concept for Use of Coriolus Versicolor As Immunonutrition in IPV Patients With Cervical Lesions, Medical News Today.

Coriolus, www.cocoonnutrition.org.

Coriolus Versicolor, University of California, San Diego Complementary and Alternative Therapies for Cancer Patients.

About the author

Barbara is a school psychologist, a published author in the area of personal finance, a breast cancer survivor using “alternative” treatments, a born existentialist, and a student of nature and all things natural.

Source: NaturalNews – http://www.naturalnews.com/025455.html

Clinical Trial Results Show Proof-of-Concept For Use Of Coriolus Versicolor As Immunonutrition In HPV Patients With Cervical Lesions (LSIL)

(Medical News Today – 4/29/2008) The results of a year long clinical trial examining the effects of mushroom supplementation in patients with Human Papillomavirus (HPV) have recently been presented at congress. Dr. Jose Silva Couto and Dr. Daniel Pereira da Silva of the Cervical Pathology Unit of the Portuguese Institute of Oncology in Coimbra, Portugal presented their findings at the 20th European Congress of Obstetrics and Gynaecology, in Lisbon Portugal. This study provides a promising set of results and demonstrates proof-of concept for the question as to whether immunonutrition supplements can be successfully used to improve HPV status in patients.

The poster presentation detailed the results of the evaluation of the Efficacy of Coriolus versicolor Supplementation in patients infected with HPV with low-grade squamous intraepthithelial lesions (LSIL). The Coriolus versicolor mushroom supplied for the study was produced by Mycology Research Laboratories Ltd in tablet form (500 mg/tablet).

Dr. Silva Couto et al. found that Coriolus versicolor supplementation over a period of one year substantially increased regression of the dysplasia (LSIL) and induced clearance of the high risk sub-types of the HPV virus responsible for cervical cancer.

a) Coriolus versicolor supplementation demonstrated a 72% regression rate in LSIL lesions compared to 47.5% without supplementation.

b) Coriolus versicolor supplementation demonstrated a 90% regression rate in the high risk HPV virus sub-types compared to 8.5% without supplementation.

Study Design

The year long study was funded by Mycology Research Laboratories Ltd. The Portuguese pharmaceutical firm Aneid-Produtos Farmacêuticos Lda acted as collaborative partners.

Forty-three (43) patients with HPV Lesions (LSIL) were divided into two groups:

– A Control group (21 patients) who did not receive any treatment

– A treatment group (22 patients) who each received Coriolus versicolor supplementation for a period of one year (6 tablets/day i.e. 3g/day)

Protocol Design

At first observation, patients were examined with colposcopy, biopsy and HPV tipification (hybrid capture). Cervical cytology exams (Pap smear tests) determined the patients’ LSIL status and this was confirmed through colposcopy and biopsy.

Four months after the first observations, colposcopy and cervical cytology was again carried out on all patients. At the same time, there was an evaluation of the possible side effects from Coriolus supplementation.

After one year, (at the end of the supplementation period), colposcopy, cervical cytology and HPV typing were carried out on all patients.

Success Parameters

The authors measured the efficacy of Coriolus supplementation in LSIL patients in terms of the evolution of HPV status from High Risk HPV+ status to High Risk HPV- status. High Risk HPV, refers to certain strains of HPV that are known to be associated with causing cervical cancer, such strains include HPV 16, 18, 31 and 45. The persistence of cervical lesions as measured by colposcopy and cytology was also determined.

Study Population

Out of the 43 patients enrolled, 39 completed the trial. Of the four (4) who did not complete the trial, 1 patient left the country and 3 discontinued supplementation due to mild side-effects. The side-effects were not serious and did not warrant further medical intervention.

The age distribution of the two groups was very similar. Patients receiving Coriolus versicolor supplementation had an average age of 31.7 years (minimum age of 19, maximum age of 49 years). The control group had an average age of 33.4 years (minimum age of 19 and a maximum of 51 years).

Results

Of the 39 patients who completed one year of follow-up, 18 took Coriolus supplementation, while the other 21 patients received no therapy (Control group). After 1 year 13 of the 18 patients in the Coriolus group showed normal cervical cytology (72.5%) while only 10 of the patients in the control group did (47.5%).

Of the 39 patients, 22 were positive for high risk HPV subtypes.10 of these patients were in the Coriolus group and 12 in the control group. After 1 year 9 of the 10 in the Coriolus group had reverted to HPV- status (90%) while only 1 of the 12 in the control group had (8.5%).

What do these results mean for HPV patients?

The results from this study are encouraging and provide insight into the effectiveness of Coriolus versicolor as a useful immunonutrition agent. Using Coriolus supplementation for one year resulted in 72.5% of recipients reverting to normal cytology compares with only 47.5% of the control group. Encouragingly, 90% of the Coriolus recipients reverted to a HPV- status compared with only 8.5% in the control group.

While the study sample size is limited in number, the results strongly suggest that using Coriolus versicolor as a food supplementation agent offers doctors a useful nutritional tool when treating HPV (LSIL) patients over the age of 35 or those HPV (LSIL) patients with compromised immune systems.

It is also likely that Coriolus versicolor could be beneficial in HSIL patients who have undergone surgery but who experience recurrent lesions caused by persistent HPV viral infection; the eradication or “control” of the viral infection is key to both LSIL and HSIL patient care.

According to Dr Silva Couto, one of the study authors “At present, we believe that the optimal supplementation period may actually be as short as six months. Further testing is required to determine the best way to reduce the time period from the one year period used in this study.”. A shorter period of treatment would aid compliance as well as reducing the already minimal overall cost of therapy.

Why Coriolus versicolor?

As already stated, the mushroom Coriolus versicolor has been used in traditional Asian medicine for a long time. It is now known that Coriolus contains high quantities of Beta-glucans that act to stimulate the immune system. Studies have shown that Coriolus can double the number of natural killer cells after only 8-weeks of treatment.1,2 The benefits of treatment with the fungus has also been tested in patients with chronic fatigue syndrome. Coriolus versicolor (strain CV-OH1) is grown aseptically on sterile, edible grain, harvested and then produced as a tablet following good manufacturing practice according to pharmaceutical guidelines. It is free from pesticide, heavy metals and contaminants.

1. Jean A. Monro, Chronic Fatigue Immune Dysfunction Syndrome. J Integrative Medicine 2004;8:101-108

2. Jean A. Monro Treatment of Cancer with Mushroom Products. Arch Env Health 2003;58:533-537

Source: Medical News Today
http://www.medicalnewstoday.com/articles/105573.php