Tag Archives: coriolus versicolor psp

Immunomodulating Actions of PSP

PsP, the protein-bound polysaccharide, extracted from a strain of Coriolus versicolor (Cov-1) by Professor Qing-yao Yang, has been proved to be effective against tumor both in animal experiments and in clinical patients. Previous results suggested that the antitumor effects of PsP were related to the potentiation of immunological responses, especially T-cell mediated immune responses of tumorbearing hosts. Since T-lymphocytes play an important role in immune response and T-cell deficiency existed in many diseases, the most noticeable one at present time is the acquired immune deficient syndrome (AIDS) which leads to the failure of T-cell functions and death. Until now there is no any
effective drug in curing this disease. It is of great interest to investigate if PsP can potentiate T-cell functions and restore the immune deficient conditions in tumor, AIDS and other viral infections. In this paper both in vivo and in vitro experiments were used to study PsP on: 1) immune organ weights, 2) antibody informations, 3) serum complement contents, 4) T lymphocyte proliferations, 5) interleukin-2 production, 6) delayed type hypersensitivity reaction, 7) phagocytic ability of reticulo-endothelial system and 8) protection of liver injuries from CCl4 intoxication.

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CIMER – Coriolus versicolor (mushroom) – MD Anderson Cancer Center Page 1

Mushrooms have traditionally been valued in Asia for their nutritional and medicinal qualities. The Coriolus versicolor or “Turkey Tail” mushroom has been investigated in numerous laboratory, animal and human clinical studies. Most of these studies have demonstrated that it does appear to have significant antimicrobial, antiviral and antitumor properties when used as a supplement to chemotherapy and/or radiotherapy. Human trials have included randomization, a process that decreases bias, but only one has used blinding, which would make them even more protected against biases.

The anti-cancer and immune stimulating properties of Coriolus versicolor have been attributed to two extracts from its cultured mycelium (thread-like extensions). These extracts are both protein-bound polysaccharides known as polysaccharide K (PSK) and polysaccharide-peptide (PSP).  Hot water is required to extract these active components.

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What is Coriolus Versicolor?

Coriolus Versicolor is the most well researched mushroom in the world. Coriolus versicolor (formerly known as Trametes versicolor, Polyporus versicolor) is a mushroom that grows on tree trunks. In Japan it is known as kawaratake (“mushroom by the river bank”), and in China it is called Yun Zhi or “cloud fungus.” This mushroom, which has long been treasured in the Far East is now accepted worldwide for its effectiveness and safety of use. It has been more intensively researched around the world than any other mushroom species.

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Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population

Recent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs. Here, we report that PSP, an active component extracted from the mushroom Turkey tail (also known as Coriolus versicolor), is effective in targeting prostate CSCs. We found that treatment of the prostate cancer cell line PC-3 with PSP led to the down-regulation of CSC markers (CD133 and CD44) in a time and dose-dependent manner. Meanwhile, PSP treatment not only suppressed the ability of PC-3 cells to form prostaspheres under non-adherent culture conditions, but also inhibited their tumorigenicity in vivo, further proving that PSP can suppress prostate CSC properties. To investigate if the anti-CSC effect of PSP may lead to prostate cancer chemoprevention, transgenic mice (TgMAP) that spontaneously develop prostate tumors were orally fed with PSP for 20 weeks. Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer.

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Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30

Breast cancer is one of the most frequent cancers in the world (1), and it is the commonest cancer amongst women (1,2). The mortality of breast cancer is low (1), however, because of its high incidence and the increasing global trend (1,3,4), it results in medical costs worldwide estimated to be more than.

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CORIOLUS MUSHROOM: Uses, Side Effects, Interactions and Warnings – WebMD

Coriolus mushroom is a fungus. People have used the fruiting body and other parts as folk medicine for a long time. Recently, researchers have started to isolate and identify substances in coriolus that might act like pharmaceutical drugs. Two of these substances are polysaccharide peptide (PSP) and polysaccharide krestin (PSK). Scientists think these chemicals might be able to fight cancer and boost the immune system. Coriolus mushroom, PSP, and PSK are used for stimulating the immune system; treating herpes, chronic fatigue syndrome (CFS), hepatitis, and pulmonary disorders; reducing phlegm; improving bodybuilding results; increasing energy; curing ringworm and a skin condition called impetigo; treating upper respiratory, urinary, and digestive tract infections; curing liver disorders including hepatitis; reducing the toxic effects and pain of chemotherapy and radiation therapy; increasing the effectiveness of chemotherapy; prolonging life and raising the quality of life of cancer patients; and increasing appetite.

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Clinical trail China phase 1

Polysaccharide-peptide (PSP) is a protein bound polysaccharides isolated from the COV-1 strain of Yunzhi (Coriolous versicolor mushroom) and made from modern alcohol extraction techniques. Each capsule contains 0.34 grams of PSP. Experimental in-vitro and in-vivo studies have shown PSP inhibits the proliferation of cancer cells including P338 leukemia cells, S 180 cells, Ehrlich ascites, and stomach and lung cancer cells. It also inhibits the growth of some tumors such as the lymphatic tumor of human skin tissue cells. In addition, PSP affects the immune system of mice by stimulating the production of ?\interferons, increasing the phagocytic index and metabolic rate of the reticuloendothilial system and by raising the HC 50 (median hemolytic dose), IgG and PFC (plaque forming cell) values. Human in-vivo experiments have also shown PSP can modulate the immune system by helping to prevent and partly eliminate the side effects of radiation and chemotherapeutic agents used by cancer patients.

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Yun zhi (Cloud Mushroom) PSP Extract- West Nile Virus and Yun zhi PSP

Yun zhi (Cloud Mushroom) PSP Extract

West Nile Virus and Yun zhi PSP

Now that it seems the worse of the SARS virus is over, a new virus is now being tested for its possible spread in the Lower Mainland. Last year, West Nile Virus was detected in the American states of Idaho, Montana, and Washington. It is expected this year that migrating birds will bring the virus into BC this summer.

West Nile Virus is a disease that is carried by birds, such as crows and ravens. However, it can be transmitted between birds and humans by mosquitoes. Now that warmer weather is approaching there is concern that the virus will spread. Protecting yourself against the spread of this infection can come in many forms. Among those are long sleeved shirts and pants, DEET-based mosquito repellent, and controlling the areas where mosquitoes can breed. The first line of defense however, is the one that everyone was born with – your immune system. The immune system is a vital part of any organism, and protects against invasion by viruses, bacteria, pollen, and other forms of infection. Without a healthy immune system, the body is unable to fight off infections, leading to symptoms that can include fever, body aches, and a rash.

Once a microorganism enters the body, it can multiply, and be toxic to the body’s biochemistry and other organs, or the multiplying microorganism can produce toxins to make the body ill. A healthy immune system will hopefully recognize the presence of these microorganisms as “foreign”, and immediately mobilize itself to produce white blood cells, antibodies, and other proteins to identify and destroy the invading foreign infectious agents.

For most people with healthy immune systems, these symptoms of West Nile Virus will usually disappear after about a week. However, one percent of those affected could experience more severe symptoms, such as confusion, headaches and paralysis, if their immune system cannot learn how to make the antibodies and other biochemicals that are needed to destroy the infecting virus. These people could then develop further complications such as meningitis or encephalitis. Ten percent of those people could die from the disease.

A weakened immune system can be caused by a combination of factors that can include stress, environment, aging, depression, and/or recent illness. Increasingly, many people are paying attention to what is called an alternative approach to health. It essentially involves taking care of the body, particularly the immune system, so that the body can take care of disease.

One approach can be the use of herbal remedies such as Yun zhi mushroom extract. It is only relatively recently that the world has become aware of the immuno-modulating properties of Yun zhi polysaccharides, but extensive research and clinical trials have shown that the regular use of natural Yun zhi can be effective in improving immune system function and response by increasing components of the immune system such as white blood cells, T-cells and B-cells.

Yun zhi polysaccharides have been used in the treatment of cancer and hepatitis in China and Japan for years. Patients who have used natural Yun zhi report increased strength and well-being, increased resistance to colds, flu, reduced fatigue and nausea, as well as regaining a normal appetite. Boosting the immune system through the regular use of natural Yun zhi could therefore provide increased protection against the threat of the West Nile Virus.

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