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PSP

Immunomodulating Actions of PSP

PsP, the protein-bound polysaccharide, extracted from a strain of Coriolus versicolor (Cov-1) by Professor Qing-yao Yang, has been proved to be effective against tumor both in animal experiments and in clinical patients. Previous results suggested that the antitumor effects of PsP were related to the potentiation of immunological responses, especially T-cell mediated immune responses of tumorbearing hosts. Since T-lymphocytes play an important role in immune response and T-cell deficiency existed in many diseases, the most noticeable one at present time is the acquired immune deficient syndrome (AIDS) which leads to the failure of T-cell functions and death. Until now there is no any
effective drug in curing this disease. It is of great interest to investigate if PsP can potentiate T-cell functions and restore the immune deficient conditions in tumor, AIDS and other viral infections. In this paper both in vivo and in vitro experiments were used to study PsP on: 1) immune organ weights, 2) antibody informations, 3) serum complement contents, 4) T lymphocyte proliferations, 5) interleukin-2 production, 6) delayed type hypersensitivity reaction, 7) phagocytic ability of reticulo-endothelial system and 8) protection of liver injuries from CCl4 intoxication.[…]

Research Papers by Year and Research Institutes | Yunzhi-PSP

Comparsion of Anti-cancer Effect between two kinds of Polysaccharide Peptide of Coriolus versicolor on Human Tumor Cell Lines in Vitro{…}

Studies and research made on PSP | Yunzhi-PSP

In terms of the survival time of mice in oxygen-lacking conditions, PSP test group has a much higher ability of anoxia tolerance.[…]

Trametes versicolor – Wikipedia, the free encyclopedia

Trametes versicolor — formerly known as Coriolus versicolor and Polyporus versicolor — is an extremely common polypore mushroom which can be found throughout the world. Versicolor means ‘of several colours’ and it is true that this mushroom is found in a wide variety of different colours. T. versicolor is commonly called Turkey Tail in the United States because of its resemblance to the tail of the wild turkey. T. versicolor is recognized as a medicinal mushroom in Chinese medicine under the name yun zhi (simplified Chinese: ??, traditional Chinese: ? ?). In China and Japan T. versicolor is used as in immunoadjuvant therapy for cancer.[…]

CIMER – Coriolus versicolor (mushroom) – MD Anderson Cancer Center Page 1

The anti-cancer and immune stimulating properties of Coriolus versicolor have been attributed to two extracts from its cultured mycelium (thread-like extensions). These extracts are both protein-bound polysaccharides known as polysaccharide K (PSK) and polysaccharide-peptide (PSP). Hot water is required to extract these active components. {…}

Yun Zhi Polysaccharopeptide (PSP) and the general aspects of its research

Yun Zhi Polysaccharopeptide (PSP) is a new type of BRM (Biological Response Modifier) extracted from the deep layer cultivated mycelia of Cov-1 strain of Yun Zhi (Coriolus versicolor). Its active ingredient is a protein bound polysaccharide used in the BRM therapy of tumours. Its characteristics and the general aspects of its research are briefly introduced in this paper[…]

Chinese Herb List – Coriolus versicolor (Yunzhi)

Cloud mushroom contains several saccharides including polysaccharide peptide (PSP) and polysaccharide-K (PSK, krestin). The protein bound polysaccharides have been found to be immune-modulating and anti-tumor, and their polypeptide moieties are rich in aspartic acid and glutamic acid. By gas chromatography and HPLC, PSP has proved that in addition to glucose, it also contains five other monosaccharides – mannose, xylose, galactose, rhamnose and arabinose. The polysaccharide peptides can be found in the mycelium, while the fruiting body mainly contains polysaccharides{…}

Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population

Recent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs. Here, we report that PSP, an active component extracted from the mushroom Turkey tail (also known as Coriolus versicolor), is effective in targeting prostate CSCs. We found that treatment of the prostate cancer cell line PC-3 with PSP led to the down-regulation of CSC markers (CD133 and CD44) in a time and dose-dependent manner. Meanwhile, PSP treatment not only suppressed the ability of PC-3 cells to form prostaspheres under non-adherent culture conditions, but also inhibited their tumorigenicity in vivo, further proving that PSP can suppress prostate CSC properties. To investigate if the anti-CSC effect of PSP may lead to prostate cancer chemoprevention, transgenic mice (TgMAP) that spontaneously develop prostate tumors were orally fed with PSP for 20 weeks. Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer.[…]

Mushroom Compound Suppresses Prostate Tumors

ScienceDaily (May 24, 2011) — A mushroom used in Asia for its medicinal benefits has been found to be 100 percent effective in suppressing prostate tumour development in mice during early trials, new Queensland University of Technology (QUT) research shows.

Dr Ling, from the Australian Prostate Cancer Research Centre-Queensland and Institute for Biomedical Health & Innovation (IHBI) at QUT, said the results could be an important step towards fighting a disease that kills 3,000 Australian men a year.[…]

CORIOLUS MUSHROOM: Uses, Side Effects, Interactions and Warnings – WebMD

Cancer when used with chemotherapy. Taking polysaccharide krestin (PSK), a substance found in coriolus mushroom, may improve some cancer patients’ response to chemotherapy. PSK has been used in Japan for several decades for breast cancer, esophageal cancer, gastric cancer, lung cancer, hepatic cancer, colorectal cancer, and nasopharyngeal cancer. Results have varied.