Category Archives: Inflammatory

How inForce immune builder rebuilt ones immunes system that was compromised by the West Nile Virus.

Brenda Koker says:
I recently discovered in March 2010 that I had a very high C – reactive protein level of 20.4. The normal range for this level is below 3. I was diagnosed in July 2004 with having been exposed to the West Nile Virus and I knew I had been sick allot and running a elevated temperature for months visiting the urgent care department every 6 weeks and taking antibiotics. I would no more be off the antibiotics for a week to 10 days and I was right back to seeing the doctors at urgent care. The doctors had put me through a series of test and scans to determine the point of origin of the inflammation, with no success. After appearing on a local TV show and following the advice of the doctor to help take some weight off and become healthier. I realized this alone was not going to help me reduce the inflammation in my body. With three months of a strict diet and exercise program my C – reactive protein level had only dropped 3.4 points to 17. Fortunately with being a distributer through InLife and believing in the products, Inforce was released in August. After receiving my first shipment of Inforce I started taking 1 capsule in the morning and 1 in the evening every day. I had more lab work done two months after taking my first dose of Inforce and my level had dropped to 13, so 4 points just being on a maintenance dose. My husband and I went down to an InLife training on September 11 th and heard additional testimonies on how Inforce was helping others with their medical issues. After hearing how much of inforce they were taking I decided to triple up on my dose to see what the result would have on my C – reactive protein level. I received my lab results Thursday and my level had dropped to 8, so 5 points and this was only in a 30 day period, not over a 60 day period like the last test done. Knowing my diet and exercise regiment had not been as strict the first 90 days as the last 90 days, I know that Inforce has helped strengthen my immune system to where it can fight off this inflammation I have in my body. This last 6 years struggling with my health, catching everything that came my way, that a simple handshake put me in jeopardy of getting sick, with knowing that after the West Nile Virus had ravaged my immune system. I can now be assured, that I can enjoy being around others and not worry about being exposed to common colds or a virus with inForce helping me to strengthen my immune system. Currently Jim and I are taking inforce and recently our Labrador/Golden Retriever at the age of 14 was diagnosed with three tumors and with her age the vet stated just keep her comfortable that she is too old to go through surgery and most likely would bring on additional infections. So we decided to put Little Bear on inForce, she has been on it for a month now and we are monitoring her to see if Inforce would help strengthen her immune system also.

Inflamed prostate reduced and improved by inLifes, inForce immune builder.

Two years ago I was diagnosed with an inflamed prostate, which, was giving me a constant severe ache in that area, and also making walking very painful.

Three weeks ago I started taking inForce, and in just a few days I had no pain at all. Obviously I need to see my doctor, to confirm any improvement, but from the way I feel, and from the total absence of pain, it would seem that the inflammation is remarkably reduced, and is not now causing any pressing problems.

I really can’t say how ecstatic I am about InForce, it is truly an amazing natural remedy, and I would advise anybody, without any doubt, to try it.

To everybody, and especially Inlife.

Many very happy Regards.

John Thomas.

Polysaccharide peptides from COV-1 strain of Coriolus versicolor induce hyperalgesia via inflammatory mediator release in the mouse.

Polysaccharide peptide (PSP), isolated from Coriolus versicolor COV-1, has been widely used as an adjunct to cancer chemotherapy and as an immuno-stimulator in China. In this study, the anti-nociceptive effects of PSP were investigated in two different pain models in the mouse. In the acetic acid-induced writhing model, initial studies showed that PSP decreased the number of acetic acid-induced writhing by 92.9%, which, by definition, would constitute an analgesic effect. However, further studies showed that PSP itself induced a dose-dependent writhing response. Studies on inflammatory mediator release showed that PSP increased the release of prostaglandin E2, tumor necrosis factor-alpha, interleukin-1beta, and histamine in mouse peritoneal macrophages and mast cells both in vitro and in vivo. The role of inflammatory mediator release in PSP-induced writhing was confirmed when diclofenac and dexamethasone decreased the number of writhing responses by 54% and 58.5%, respectively. Diphenhydramine totally inhibited the PSP-induced writhhttp://mushroomstudies.co/wp-admin/post-new.phping. In the hot-plate test, PSP dose-dependently shortened the hind paw withdrawal latency, indicative of a hyperalgesic effect. The hyperalgesic effect was reduced by pretreatment with the anti-inflammatory drugs. In conclusion, the PSP-induced hyperalgesia was related to activation of peritoneal resident cells and an increase in the release of inflammatory mediators.

PMID: 16310221 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/16310221

Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways.

Lee CL, Sit WH, Jiang PP, So IW, Wan JM.

School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China.

Abstract

The activation of T helper (Th) cell subsets plays an important role in the human immune system. Uncontrolled Th1 and Th2 responses lead to autoimmune and inflammatory diseases, respectively. The identification of agents that modulate the Th1/Th2 cytokines is therefore essential for controlling these diseases. We recently reported that polysaccharopeptide (PSP) from Coriolus versicolor exhibited ciclosporin-like activities to control aberrant T lymphocyte activation. Here, we compared the properties of PSP with ciclosporin on cell proliferation, CD25+ expression, secretion of Th1/Th2 cytokines and activation of mitogen-activated protein kinase (MAPK)p38 and signal transducers and activators of transcription 5 (STAT5) on T cells. The data show that PSP alone suppresses the proliferation of activated T cells. PSP exhibited similar and additive inhibitory effects to ciclosporin to suppress activated T cell proliferation, Th1 cytokines and reduce CD3+/CD25+ cell expression, but not Th2 cytokine expression, which helps the cytokine balance shift towards Th2 dominance. These suppressive actions of PSP involved the MAPKp38 and STAT5 pathways. These findings refine our understanding of the effects of PSP on T lymphocytes and its adjuvant properties with the immunosuppressant ciclosporin for possible control of autoimmune diseases.

PMID: 18957170 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/18957170