Effects of the immunomodulator PSK on the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) to 5-fluorouracil (5-FU) were examined in 10 patients with advanced gastric cancer and who had undergone curative resection. PSK is a protein-bound preparation, extracted from Coriolus versicolor and belongs to Basidiomycetes. The 5-FU concentration in the plasma was 0.024 micrograms/ml at 15 min after the intravenous injection of 400 mg of tegafur and the area under the curve of 5-FU was 0.58 micrograms.h/ml. Following administration of PSK, 3 g/day for 8-14 months, there was no change in the plasma level of 5-FU, in any patient. As the clinical dose of PSK had no apparent influence on the metabolism of tegafur to 5-FU, the combination of PSK and tegafur can be prescribed to treat patients with advanced gastric cancer.
What Hartford Hospital in Conneticut has to say about Coriolus Versicolor
“Currently, extracts of Coriolus versicolor called polysaccharide-K (PSK) and polysaccharopeptide (PSP) are under study as immune stimulants for use alongside chemotherapy in the treatment of cancer. These two related substances, made from slightly different strains of the fungus, are thought to act as “biological response modifiers,” meaning that they affect the body’s response to cancer.
According to most but not all reported trials, most of which were performed in Asia, both PSK and PSP can enhance the effects of various forms of standard cancer treatment. For example, in a 28-day double-blind , placebo-controlled study of 34 people with advanced non–small-cell lung cancer, use of Coriolus extracts along with conventional treatment significantly slowed the progression of the disease.
It is thought that Coriolus extracts work by stimulating the body’s own cancer-fighting cells. PSK and PSP may also have cancer-preventive effects.
In addition, very weak evidence hints that extracts of Coriolus versicolor might be helpful for HIV infection.”