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PSP, Coriolus Polysaccharide: Intra-Cellular Mycelia Extract of Coriolus Versicolor

As the leader in standardized mushroom extracts we believe passionately in sharing information from the growing body of published research on medicinal mushrooms. This is for education purposes only and MYCOPHARMA® cannot and does not vouch for the accuracy of independent research. To make your own informed decisions please refer to the original published research about Coriolus Versicolor.{…}

Trametes versicolor – Wikipedia, the free encyclopedia

Trametes versicolor — formerly known as Coriolus versicolor and Polyporus versicolor — is an extremely common polypore mushroom which can be found throughout the world. Versicolor means ‘of several colours’ and it is true that this mushroom is found in a wide variety of different colours. T. versicolor is commonly called Turkey Tail in the United States because of its resemblance to the tail of the wild turkey. T. versicolor is recognized as a medicinal mushroom in Chinese medicine under the name yun zhi (simplified Chinese: ??, traditional Chinese: ? ?). In China and Japan T. versicolor is used as in immunoadjuvant therapy for cancer.[…]

Chinese Herb List – Coriolus versicolor (Yunzhi)

Cloud mushroom contains several saccharides including polysaccharide peptide (PSP) and polysaccharide-K (PSK, krestin). The protein bound polysaccharides have been found to be immune-modulating and anti-tumor, and their polypeptide moieties are rich in aspartic acid and glutamic acid. By gas chromatography and HPLC, PSP has proved that in addition to glucose, it also contains five other monosaccharides – mannose, xylose, galactose, rhamnose and arabinose. The polysaccharide peptides can be found in the mycelium, while the fruiting body mainly contains polysaccharides{…}

Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population

Recent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs. Here, we report that PSP, an active component extracted from the mushroom Turkey tail (also known as Coriolus versicolor), is effective in targeting prostate CSCs. We found that treatment of the prostate cancer cell line PC-3 with PSP led to the down-regulation of CSC markers (CD133 and CD44) in a time and dose-dependent manner. Meanwhile, PSP treatment not only suppressed the ability of PC-3 cells to form prostaspheres under non-adherent culture conditions, but also inhibited their tumorigenicity in vivo, further proving that PSP can suppress prostate CSC properties. To investigate if the anti-CSC effect of PSP may lead to prostate cancer chemoprevention, transgenic mice (TgMAP) that spontaneously develop prostate tumors were orally fed with PSP for 20 weeks. Whereas 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer.[…]

NCI Drug Dictionary

An extract derived from the mushroom Coriolus versicolor, containing polysaccharide K (PSK) and polysaccharidepeptide (PSP), with potential immunomodulating and antineoplastic activities. Coriolus versicolor extract has been shown to stimulate the production of lymphocytes and cytokines, such as interferons and interleukins, and may exhibit antioxidant activities. However, the precise mechanism of action(s) of this agent is unknown. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)[…]

Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30

This work was partially supported by the RGC grant HKU 7511/03M of the University of Hong Kong and the Hong Kong Association for Health Care, Hong Kong, SAR, P.R. China. […]

CORIOLUS MUSHROOM: Uses, Side Effects, Interactions and Warnings – WebMD

Cancer when used with chemotherapy. Taking polysaccharide krestin (PSK), a substance found in coriolus mushroom, may improve some cancer patients’ response to chemotherapy. PSK has been used in Japan for several decades for breast cancer, esophageal cancer, gastric cancer, lung cancer, hepatic cancer, colorectal cancer, and nasopharyngeal cancer. Results have varied.

Beth Israel Deaconess Medical Center – A Teaching Hospital of Harvard Medical School

In addition, very weak evidence hints that extracts of Coriolus versicolor might be helpful for HIV infection[…}

Clinical Trial China phase 3

Based on the PSP´s significant findings in the investigated cancers of the Phase II trial, permission was granted by the Chinese Administration of Health Bureau to carry out a multi-center Phase III clinical trial. Fourteen hospitals including the eight who participated in the phase II trial conducted this randomized study from April 1996 to September 1997.[…]

Bioactive Polysaccharides from TCM Herbs as Anti-Cancer Adjuvants

Bio-active polysaccharides occur extensively in TCM herbs and is the basis of potential useful application of TCM as adjuvant in
cancer therapies.[…]