Adjuvant therapy with protein-bound polysaccharide K and tegafur uracil in patients with stage II or III colorectal cancer: randomized, controlled trial.

PURPOSE: Intravenous fluorouracil and leucovorin for six to eight months is currently a standard adjuvant treatment for Stage III colon cancer; however, this regimen is complex, inconvenient, and has a high intolerability. Adjuvant chemotherapies are claimed for objective response rates with an acceptable safety profile and complexity. We investigated the benefits of oral protein-bound polysaccharide K added to oral tegafur/uracil on curatively resected Stage II or III colorectal cancer. METHODS: We prospectively randomized 207 patients to treatments of either oral 3.0 g protein-bound polysaccharide K plus 300 mg tegafur/uracil or 300 mg tegafur/uracil alone for two years following 12 mg/m2 and 8 mg/m2 mitomycin treatment on postoperative Days 1 and 2, respectively. The primary end points were disease-free and overall survival, and recurrence rates. RESULTS: Three (1.4 percent) patients were declared ineligible, and three patients did not start treatment. In total, 201 patients were analyzed. The three-year, disease-free survival rate was 80.6 percent (standard error = 3.4 percent) in the protein-bound polysaccharide K group (P = 0.02) compared with 68.7 percent (SE = 5.7 percent) in the control group after a median follow-up of 3.7 years. The estimated relative risk of recurrence in the control group was 1.87 (95 percent confidence interval, 1.10-3.20) at three years. The three-year, overall survival rate was 87.3 percent (standard error = 2.9 percent) in the protein-bound polysaccharide K group and 80.6 percent (standard error = 4.8 percent) in the control group (P = 0.24). The three-year, overall survival rate in 80 pathological TNM Stage III patients was 83.0 percent (standard error = 5.2 percent) in the protein-bound polysaccharide K group and 59.3 percent (standard error = 9.5 percent) in the control group (P = 0.02). Protein-bound polysaccharide K prevented distant metastases (P = 0.05), particularly lung metastases (P = 0.01). The incidence of adverse effects was minimal, and compliance was good. CONCLUSION: Adjuvant therapy using a combination of oral protein-bound polysaccharide K and tegafur/uracil is highly effective in preventing the recurrence of colorectal cancer in Stage II or III patients, and increases overall survival in pathological TNM Stage III. These results will be a sufficient proof to conduct a larger study to compare tegafur/uracil/protein-bound polysaccharide K with 5-fluorouracil/leucovorin.

Introducing inForce Immune Builder

Irvine, California (September 7, 2010) inLife, LLC, distributors of science-based Health & Wellness products, today introduced inForce Immune Builder, a new product that clinical research shows helps stimulate the body’s immune system. inForce’s main ingredient, the Coriolus versicolor mushroom mycelia extract, is one of the most widely studied supplements for its immune building properties and is now available to the public and the direct-selling industry. Worldwide, there have been over 400 animal and human studies on Coriolus versicolor, with over a dozen placebo-based human trials conducted in the west.

inLife Immune Builder with PSP and PSK
inLife offers Coriolus versicolor as a Daily Dietary Supplement in vegan capsule form to help maintain and stimulate the body’s immune system. Coriolus versicolor, PSK and PSP are among the most widely studied supplements for their immune building properties. One would be hard pressed to find another immune boosting product that has had more research completed or positive comments associated with it. The amount of worldwide comments and studies is compelling. inForce Immune Builder is a proprietary blend of both Polysaccharide-K (PSK) and Polysaccharide Peptide (PSP). Both offer much-needed immune building assistance and they can be taken on a daily basis. The products are bottled in the United States in an FDA-registered bottling facility that is cGMP compliant (Current Good Manufacturing Practices).

Hospital and Research Institutes Report on Coriolus Versicolor
In the United States, top-ranked hospital and research institutes have reported that “Coriolus versicolor, PSK and PSP help boost the body’s immune system with limited side effects and safety of daily oral doses for extended periods of time.” In addition, Coriolus versicolor and its potential positive effects has been studied very closely by M.D. Anderson, University of Texas, Loma Linda University, Beth Israel Deaconess Medical Center (a teaching hospital of Harvard Medical School) , The University of San Diego, Sloan-Kettering Center (New York), and Bastyr University (Kenmore, Washington), just to name a few.

About inLife, LLC
Founded in 2007, inLife has been very successful in bringing to the market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain. For more information on inForce Immune Builder and the company, please review www.myinlife.com. For further details on inForce, journalists may contact Thomas Kiklas directly at 949-648-2525.

# # #

Founded in 2007, inLife has been very successful in bringing to the market products that have efficacies that are soundly based on scientific research. inLife products are now available in the U.S. as well as the U.K, Canada and Spain.

Click here to download this press release.

Mushroom immunutrition in Chronic Fatigue Immune Dysfunction Syndrome

In the recently published edition of the Journal of Integrated Medicine (Online version), Dr. Jean Monro of the Breakspear Hospital outlines the impact of Coriolus versicolor supplementation as immunonutrition in thirty-six (36) Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) patients over a six week period.

The 36 patients were selected on the basis of international criteria for the diagnosis of CFIDS. Ages ranged from 17 years to 83 years and there was a female-to-male ratio of 2:1. In addition, the patients had a combination of high antibody levels to Epstein Barr virus (EBV) and/or Herpes Simplex 6 virus (HHV6) and/or Cytomegalovirus. (CMV).

Patients were given Coriolus versicolor (non-extracted) 6 tablets daily for 15 days (3 g/day), followed by 3 tablets daily for 45 days (1.5 g/day). Immune parameters were measured before and after the sixty (60) day supplementation period.

Results were noted in two areas:

1) Natural Killer Cells–before treatment the average NK cell level was average=129.64/mm3. After treatment this had increased to 175/mm3, an increase of 35%.

2) T cells (CD3 CD26)–there was increased activation in 66% of patients and T cell depression in 22% of patients. T cell level was unchanged in 11% of the patients.

Conclusion

Supplementation with non-extracted Coriolus versicolor showed improvements in both immune parameters and viral levels in the majority of the thirty-six (36) CFIDS patients, indicating that Coriolus versicolor supplementation has the potential to play a significant role in the treatment of CFIDS.

Coriolus Versicolor is Potent Mushroom for Fighting Cancer and Autoimmune Diseases – By: Barbara L. Minton, citizen journalist

(NaturalNews – January 28, 2009) For thousands of years Chinese medicine has prized the mushroom for its energizing and healing properties. Chinese legend is filled with stories of those who discovered the 1,000 year old mushroom and became immortal. In the West, acceptance is based less on tradition and more on the results of the scientific method. Researchers have been busy scientifically documenting what Chinese tradition dictates, that mushrooms are some of the most potent medicines on the plant. Recent research findings have shown the Coriolus versicolor mushroom stands out above the rest for regulating the immune system.

Coriolus versicolor found to be effective against cancer and human papillomavirus

Researchers at the Sloan-Kettering Cancer Center in New York tested several botanicals for their immune enhancing activity using a subcutaneous immunization model of cell surface carbohydrate expression in cancer cells in a study published in September, 2008 Vaccine. They found Coriolus versicolor to display consistent and significant immune enhancement activity superior to all other coumpounds tested. The superiority of Coriolus to yeast beta-glucan, maitake, turmeric, echinacea, and preparation H-48 from Honso USA, was described as surprising. Although the exhibited levels of immune enhancing ability of astragalus was also impressive, it was surpassed by that of Coriolus.

The March, 2008 BMC Cancer reports Coriolus versicolor has shown anticancer activity with positive results in the treatment of gastric, esophageal, colorectal, breast and lung cancers. The efficacy of its protein-bound polysaccharide as an immunomodulator is credited. This activity was independent of its previously described immunomodulatory effect on NK cells.

The journal Cancer Immunology and Immunotherapy reports double blind trials on 111 patients with colorectal cancer, using Coriolus versicolor. Although traditional medicine offers little help for colon cancer patients, Coriolus showed a remarkable enhancement of the patient’s white blood cells, even in advanced colon cancer cases. The white cells greatly increased natural chemotactic motion and phagocytosis, the ability to scavenge toxins and kill pathogens. Coriolus was also used with patients as a helpful maintenance therapy following cancer surgery.

The results of a year long clinical trial examining the effects of mushroom supplementation in patients with Human Papillomavirus (HPV) were so impressive they were presented in 2008 at the 20th European Congress of Obstetrics and Gynocology. Dr. Silva Couto and his research team found that Coriolus versicolor supplementation over the period of one year substantially increased regression of dysplasia and induced clearance of the high-risk subtypes of the HPV responsible for cervical cancer. Coriolus supplementation demonstrated a 72 percent regression rate in lesions compared to 47.5 percent without supplementation, and a 90 percent regression rate in the high risk HPV virus sub-types compared to 8.5 percent without.

After using the supplement for one year, 72.5 percent of recipients reverted to normal cytology compared with only 47.5 percent of the control group. Coriolus supplementation produced a 90 percent regression rate in the high risk HPV virus sub-tupes compared to an 8.5 percent regression without supplementation.

It is also likely that Coriolus versicolor would be beneficial in high-grade squamous intraepithelial lesion (HSIL), a precancerous condition in which the cells of the uterine cervix are moderately or severely abnormal. The lead physician of the study noted that the optimal supplementation period may be as short as six months.

Coriolus versicolor modulates autoimmune diseases

T cells belong to a group of while blood cells known as lymphocytes, and play a central role in cell-mediated immunity. The activation of T helper (Th) cell subsets also plays an important role in immunity. Uncontrolled Th responses lead to autoimmune and inflammatory diseases. The identification of agents that modulate these helper cells is essential for controlling autoimmune diseases. A study from the November, 2008 Journal of Pharmacy and Pharmacology, reported that polysaccharopeptide (PSP) from Coriolus versicolor exhibited the ability to control aberrant T lymphocyte activation through ciclosporin-like activity. PSP alone suppress production of activated T cells.

What makes Coriolus versicolor special?

Coriolus versicolor, also referred to as the turkey-tail mushroom, contains large quantities of Beta-glucans that act to stimulate the immune system. Coriolus can dramatically regenerate and rejuvenate the body. Its most active medicinal components are biological response modifiers called protein-bound polysaccharides. These polysaccharides are known as Krestin or PSK in Japan, and as Yun zhi, or PSP in China. There have been reports of cases of Bell’s palsy clearing up with use of Coriolus for just a few days. Others have found it effective against bronchitis.

Other studies have shown that Coriolus can double the number of natural killer cells after only 8 weeks of treatment. Coriolus has also been found to help patients with chronic fatigue syndrome and may be an effective treatment for Lyme disease.

More research documents the anti-tumor benefits of Coriolus

Japanese researchers screened 200 of the best phytochemicals (plant extracts) known for anti-tumor activity. Coriolus versicolor was designated as exhibiting the greatest amount of anti-tumor activity. In another Japanese study, 185 people with lung cancer at different stages were given radiation. Doctors found those who also took Coriolus showed the best tumor shrinkage and the best survival rate. Another study involving stomach cancer patients produced similar results. Those who received Coriolus survived significantly longer, felt better and had fewer side effects.

Coriolus is first line defense against infection

Coriolus is a good centerpiece for your natural medicine chest, even if you are currently the picture of health. When any type of infection strikes, you will be ready. Coriolus can be used to target any infected organ, gland or tissue. Its immune enhancing properties provide an increased response to deal effectively with infections, and do this without over stimulating the immune system.

Sources:

Clinical Trial Results Show Proof of Concept for Use of Coriolus Versicolor As Immunonutrition in IPV Patients With Cervical Lesions, Medical News Today.

Coriolus, www.cocoonnutrition.org.

Coriolus Versicolor, University of California, San Diego Complementary and Alternative Therapies for Cancer Patients.

About the author

Barbara is a school psychologist, a published author in the area of personal finance, a breast cancer survivor using “alternative” treatments, a born existentialist, and a student of nature and all things natural.

Source: NaturalNews – http://www.naturalnews.com/025455.html

Add mushrooms to list of cancer treatment tools – By: Dr. Patrick Massey, M.D., Ph.D., Daily Herald Columnist

(Daily Herald – 9/8/2008) When it comes to cancer treatment, I believe that we have finally reached a point where we need to seriously consider incorporating mushrooms into the overall medical approach.

A review article outlining the importance of one specific mushroom – Coriolus versicolor – in the treatment of several types of cancer was published in the recent issue of the Journal of the Society for Integrative Oncology. The article summarizes more than three decades of solid research that showed patients who consumed Coriolus versicolor or one of its extracts during chemotherapy had better survival rates.

The use of mushrooms as a cancer therapy has been common in Asia for many years. Coriolus versicolor is often recommended because of its potent anticancer properties. This particular mushroom grows on the side of trees in many parts of the world, including the U.S. In China, it is called yun zhi (cloud fungus). In the U.S., it is commonly referred to as turkey tail.

Coriolus versicolor is the source of Krestin, arguably the most commonly used anticancer compound in the world. Krestin was first discovered by a Japanese chemical engineer in 1965 and is approved by the Japanese government as an anticancer therapy.

Standard treatments such as chemotherapy and radiation therapy can dramatically reduce the number of cancer cells in a person’s body, but ultimately the immune system is responsible for killing the remaining cancer cells. Mushrooms contain a number of unique long chain sugars called polysaccharides. Polysaccharide recognition is one way that our cells communicate and how natural killer cells differentiate between normal and cancer cells. A number of mushroom polysaccharides, especially from Coriolus versicolor, specifically enhance the activity of natural killer cells.

There is significant research to indicate that extracts from Coriolus versicolor show activity against lung, gastrointestinal and breast cancers, with more than 140 papers published in the medical literature, including 43 human clinical trials.

Although Coriolus versicolor and its extracts appear to be safe, I strongly recommend medical supervision during cancer therapy. In addition, safety in children, pregnant women and those with kidney disease has not been established.

• Dr. Patrick D. Massey, M.D., Ph.D., is medical director for complementary and alternative medicine for Alexian Brothers Hospital Network.

Source: Daily Herald, Chicagohttp://www.dailyherald.com/story/print/?id=232976

Clinical Trial Results Show Proof-of-Concept For Use Of Coriolus Versicolor As Immunonutrition In HPV Patients With Cervical Lesions (LSIL)

(Medical News Today – 4/29/2008) The results of a year long clinical trial examining the effects of mushroom supplementation in patients with Human Papillomavirus (HPV) have recently been presented at congress. Dr. Jose Silva Couto and Dr. Daniel Pereira da Silva of the Cervical Pathology Unit of the Portuguese Institute of Oncology in Coimbra, Portugal presented their findings at the 20th European Congress of Obstetrics and Gynaecology, in Lisbon Portugal. This study provides a promising set of results and demonstrates proof-of concept for the question as to whether immunonutrition supplements can be successfully used to improve HPV status in patients.

The poster presentation detailed the results of the evaluation of the Efficacy of Coriolus versicolor Supplementation in patients infected with HPV with low-grade squamous intraepthithelial lesions (LSIL). The Coriolus versicolor mushroom supplied for the study was produced by Mycology Research Laboratories Ltd in tablet form (500 mg/tablet).

Dr. Silva Couto et al. found that Coriolus versicolor supplementation over a period of one year substantially increased regression of the dysplasia (LSIL) and induced clearance of the high risk sub-types of the HPV virus responsible for cervical cancer.

a) Coriolus versicolor supplementation demonstrated a 72% regression rate in LSIL lesions compared to 47.5% without supplementation.

b) Coriolus versicolor supplementation demonstrated a 90% regression rate in the high risk HPV virus sub-types compared to 8.5% without supplementation.

Study Design

The year long study was funded by Mycology Research Laboratories Ltd. The Portuguese pharmaceutical firm Aneid-Produtos Farmacêuticos Lda acted as collaborative partners.

Forty-three (43) patients with HPV Lesions (LSIL) were divided into two groups:

– A Control group (21 patients) who did not receive any treatment

– A treatment group (22 patients) who each received Coriolus versicolor supplementation for a period of one year (6 tablets/day i.e. 3g/day)

Protocol Design

At first observation, patients were examined with colposcopy, biopsy and HPV tipification (hybrid capture). Cervical cytology exams (Pap smear tests) determined the patients’ LSIL status and this was confirmed through colposcopy and biopsy.

Four months after the first observations, colposcopy and cervical cytology was again carried out on all patients. At the same time, there was an evaluation of the possible side effects from Coriolus supplementation.

After one year, (at the end of the supplementation period), colposcopy, cervical cytology and HPV typing were carried out on all patients.

Success Parameters

The authors measured the efficacy of Coriolus supplementation in LSIL patients in terms of the evolution of HPV status from High Risk HPV+ status to High Risk HPV- status. High Risk HPV, refers to certain strains of HPV that are known to be associated with causing cervical cancer, such strains include HPV 16, 18, 31 and 45. The persistence of cervical lesions as measured by colposcopy and cytology was also determined.

Study Population

Out of the 43 patients enrolled, 39 completed the trial. Of the four (4) who did not complete the trial, 1 patient left the country and 3 discontinued supplementation due to mild side-effects. The side-effects were not serious and did not warrant further medical intervention.

The age distribution of the two groups was very similar. Patients receiving Coriolus versicolor supplementation had an average age of 31.7 years (minimum age of 19, maximum age of 49 years). The control group had an average age of 33.4 years (minimum age of 19 and a maximum of 51 years).

Results

Of the 39 patients who completed one year of follow-up, 18 took Coriolus supplementation, while the other 21 patients received no therapy (Control group). After 1 year 13 of the 18 patients in the Coriolus group showed normal cervical cytology (72.5%) while only 10 of the patients in the control group did (47.5%).

Of the 39 patients, 22 were positive for high risk HPV subtypes.10 of these patients were in the Coriolus group and 12 in the control group. After 1 year 9 of the 10 in the Coriolus group had reverted to HPV- status (90%) while only 1 of the 12 in the control group had (8.5%).

What do these results mean for HPV patients?

The results from this study are encouraging and provide insight into the effectiveness of Coriolus versicolor as a useful immunonutrition agent. Using Coriolus supplementation for one year resulted in 72.5% of recipients reverting to normal cytology compares with only 47.5% of the control group. Encouragingly, 90% of the Coriolus recipients reverted to a HPV- status compared with only 8.5% in the control group.

While the study sample size is limited in number, the results strongly suggest that using Coriolus versicolor as a food supplementation agent offers doctors a useful nutritional tool when treating HPV (LSIL) patients over the age of 35 or those HPV (LSIL) patients with compromised immune systems.

It is also likely that Coriolus versicolor could be beneficial in HSIL patients who have undergone surgery but who experience recurrent lesions caused by persistent HPV viral infection; the eradication or “control” of the viral infection is key to both LSIL and HSIL patient care.

According to Dr Silva Couto, one of the study authors “At present, we believe that the optimal supplementation period may actually be as short as six months. Further testing is required to determine the best way to reduce the time period from the one year period used in this study.”. A shorter period of treatment would aid compliance as well as reducing the already minimal overall cost of therapy.

Why Coriolus versicolor?

As already stated, the mushroom Coriolus versicolor has been used in traditional Asian medicine for a long time. It is now known that Coriolus contains high quantities of Beta-glucans that act to stimulate the immune system. Studies have shown that Coriolus can double the number of natural killer cells after only 8-weeks of treatment.1,2 The benefits of treatment with the fungus has also been tested in patients with chronic fatigue syndrome. Coriolus versicolor (strain CV-OH1) is grown aseptically on sterile, edible grain, harvested and then produced as a tablet following good manufacturing practice according to pharmaceutical guidelines. It is free from pesticide, heavy metals and contaminants.

1. Jean A. Monro, Chronic Fatigue Immune Dysfunction Syndrome. J Integrative Medicine 2004;8:101-108

2. Jean A. Monro Treatment of Cancer with Mushroom Products. Arch Env Health 2003;58:533-537

Source: Medical News Today
http://www.medicalnewstoday.com/articles/105573.php

Adjuvant PSK immunotherapy in patients with carcinoma of the nasopharynx.

A controlled study using adjuvant PSK immunotherapy in patients with nasopharyngeal carcinoma was initiated with the aim of improving survival by enhancing the host immune system against tumour cells. A total of 38 patients were randomly selected, all of whom had previously received radiotherapy with or without chemotherapy. Eight patients in the PSK immunotherapy group (n = 21) developed local recurrence, three of whom later died due to distant metastasis. In the control group (n = 17) three patients developed local recurrence while six patients developed distant metastasis. All of these six patients later died due to disease progression. It seems that PSK exerts its antitumour effect systemically; the risk of distant metastasis occurring is decreased, but it is apparently ineffective in improving local disease control. The estimated median survival time of the PSK-treated group compared with the control was significantly increased (35 months versus 25 months, P = 0.043). The 5-year survival rate was also significantly better in the PSK immunotherapy group (28% versus 15%, P = 0.043). It is concluded that PSK deserves careful consideration as an important immunotherapeutic agent in the management of nasopharyngeal carcinoma.

Adjuvant immunochemotherapy with oral Tegafur/Uracil plus PSK in patients with stage II or III colorectal cancer: a randomised controlled study

Intravenous fluorouracil and leucovorin is the standard adjuvant treatment for stage III colon cancer. However, oral adjuvant chemotherapy is attractive because it has low toxicity and greater convenience. We investigated the benefits of oral protein-bound polysaccharide K (PSK) with tegafur/uracil (UFT) as an adjuvant in stage II and III colorectal cancer. Patients were assigned to groups that received either 3 g PSK plus 300 mg UFT, or 300 mg UFT alone orally each day for a 2-year period following intravenous mitomycin C. Of 207 registered patients, 205 with stage II (n¼123) or III (n¼82) were analysed. The 5-year disease-free survival was 73.0% (95% CI 65.6–80.4%) with PSK (n¼137) and 58.8% (95% CI 47.1–70.5%) in the controls (n¼68) (P¼0.016). POLYSACCHARIDE K reduced the recurrence by 43.6% (95% CI 4.5–66.7%) and mortality by 40.2% (95% CI _12.5 to 68.3%). The 5-year survival was 81.8% (95% CI 75.3–88.2%) in the PSK group and 72.1% (95% CI 61.4–82.7%) in the control group (P¼0.056). In stage III patients, disease-free and overall survivals in patients receiving PSK were increased significantly: 60.0% (95% CI 47.1–72.9%) and 74.6% (95% CI 63.0–86.1%) in the PSK group as compared with 32.1% (95% CI 14.8–49.4%) and 46.4% (95% CI 28.0–64.9%) in the controls (P¼0.002 and 0.003, respectively). Polysaccharide K prevented recurrence, particularly lung metastases (P¼0.02; odds ratio 0.27; 95% CI 0.09–0.77). In the models, the presence of regional metastases (relative risk, 2.973; 95% CI 1.712–5.165; Po0.001), omission of PSK (relative risk, 2.106; 95% CI 1.221–3.633; P¼0.007), and higher primary tumour (relative risk, 4.398; 95% CI 1.017–19.014; P¼0.047) were each significant indicators of recurrence. Adverse effects were mild and compliance was good. Oral PSK with UFT reduced recurrence in stage II and III colorectal cancer, and increased survival in stage III.

For full article click here.

Activation of peritoneal macrophages by polysaccharopeptide from the mushroom, Coriolus versicolor.

Polysaccharopeptide (PSP) is a substance produced by an edible mushroom, Coriolus versicolor which has been claimed to possess antitumor activity.  However, neither tumoricidal activity nor cytotoxicity was observed when five tumor cell lines and mouse peritoneal macrophages were cultured in vitro in the presence of 2.5-10 ?g/ml PSP.  An increase in the production of reactive nitrogen intermediates, reactive oxygen intermediates (superoxide anions) and tumor necrosis factor was measured in peritoneal macrophages collected from inbred C57 mice which had received PSP in the drinking water for 2 weeks.  Northern blot analysis also demonstrated that PSP activated the transcription of tumor necrosis factor gene in these cells, indicating that PSP exerted an immunomodulatory effect on the defensive cells.

For full article click here.

Activation of human natural killer cells by the protein-bound polysaccharide PSK

The protein-bound polysaccharide PSK was tested for the ability to activate human natural killer (NK) cells. When blood lymphocytes and purified CD3-CD16 ÷ large granular lymphocytes (LGL) were treated in vitro overnight with PSK, they demonstrated enhanced NK cell activity against K562. The PSK-activated killer cells also lysed NK-resistant targets and freshly isolated autologous and allogeneic tumor cells. The PSK effect was observed with concentrations that could be obtained in the blood of cancer patients receiving oral administration of PSK. PSK-induced enhancement of NK activity was not abrogated by monoclonal antibodies (mAb) that neutralized interferon (IFN)o~, IFN3,, or interleukin-2 (IL-2). In addition, mAb reactive with p55 (~ chain) or p75 (/3 chain) glycoproteins of IL-2 receptors had no effects on PSK-enhanced NK activity even when used simultaneously. These results indicate that the PSK could activate human NK cells independently of IFN and IL-2/IL-2R systems.

For full article click here.