Displaying posts published in

May 2011

Basty University herbal monographs

PSK fights cancers and tumors by inhibiting the growth of cancer cells and by “stimulating a host mediated response.” Natural Killer cells are also promoted to enhance the immune system. It is often used in conjunction with chemotherapy to increase cancer survival rates. PSP is being proposed as an inhibitor of HIV replication based on an in vitro study[…]

Bioactive Polysaccharides from TCM Herbs as Anti-Cancer Adjuvants

Bio-active polysaccharides occur extensively in TCM herbs and is the basis of potential useful application of TCM as adjuvant in
cancer therapies.[…]

American Cancer Society

Available scientific evidence does not support claims that the raw mushroom itself is an effective anti-cancer agent in humans. But there is some scientific evidence that substances derived from parts of the mushroom may be useful against cancer. Clinical trials suggest that PSK may help people with certain types of cancer by increasing survival rates and lengthening periods of time without disease, without causing major side effects. PSK is commonly used with other cancer treatments in Japan. PSP and VPS have not been studied as thoroughly.[…]

Anticancer effects and mechanisms of polysaccharide?K (PSK): implications of cancer immunotherapy.

Polysaccharide-K (polysaccharide-Kureha; PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years. PSK and Polysaccharopeptide (PSP) are both protein-bound polysaccharides which are derived from the CM-101 and COV-1 strains of the fungus Coriolus versicolor by Japanese and Chinese researchers, respectively. Both polysaccharide preparations have documented anticancer activity in vitro, in vivo and in human clinical trials, though PSK has been researched longer and has therefore undergone more thorough laboratory, animal and clinical testing. Several randomized clinical trials have demonstrated that PSK has great potential as an adjuvant cancer therapy agent, with positive results seen in the adjuvant
treatment of gastric, esophageal, colorectal, breast and lung cancers. These studies have suggested the efficacy of PSK as an immunotherapy or biological response modifier (BRM). BRMs potentially have the ability to improve the “host versus tumor response,” thereby increasing the ability of the host to defend itself from tumor progression. The mechanisms of biological response modification by PSK have yet to be clearly and completely elucidated. Some studies suggest that PSK may act to increase leukocyte activation and response through up-regulation of key cytokines. Indeed, natural killer (NK) and lymphocyte-activated killer (LAK) cell activation has been demonstrated in vivo and in vitro, and recent genetic studies reveal increased expression of key immune cytokines in response to treatment with PSK. An antimetastatic action of PSK has also been demonstrated and is perhaps attributed to its potential to inhibit metalloproteinases and other enzymes involved in metastatic activity. PSK has also been shown to cause differentiation of leukemic cells in vitro, and this effect has been attributed to induction of differentiation cytokines. PSK has further been shown to have antioxidant capacity which may allow it to play a role as a normal tissue chemo- and radio-protector when used in combination with adjuvant or definitive chemotherapy and/or radiotherapy in the treatment of cancer, while it may also enable it to defend the host from oxidative stress. Interestingly, studies have also shown that PSK may actually inhibit carcinogenesis by inhibiting the action of various carcinogens on vulnerable cell lines. This action of PSK may play a role in preventing second primary tumors when an inducing agent, such as tobacco or asbestos, is suspected and may also prevent second malignancies due to the carcinogenic effects of radiotherapy and cytotoxic chemotherapy. Another very important aspect of chemoimmunotherapy, in general is that it may be used on debilitated patients such as those with AIDS and the elderly who might otherwise be denied potentially helpful adjuvant cytotoxic chemotherapy. Further determination of the mechanisms of these anti-cancer, immunostimulating and biological response modifying effects of PSK as well as of other protein-bound polysaccharides is certainly warranted. Indeed, with modern cellular and molecular biology techniques, a better understanding of the specific molecular effects of PSK on tumor cells as well as leukocytes may be determined. Much of the research that has been done on PSK is outlined in this paper and may serve as a foundation toward determining the mechanisms of action of this and other protein-bound polysaccharides in the treatment of cancer. This information may open new doors in the development of novel strategies for the treatment of malignancies using adjuvant immunotherapy in combination with surgery, chemotherapy and/or radiotherapy.[…]

Effect of Krestin as adjuvant treatment following radical radiotherapy in non?small cell lung cancer patients.

To evaluate the efficacy of Krestin (PSK) as adjuvant treatment after radical radiation therapy (RT) for non-small cell lung cancer (NSCLC), treatment results of 225 patients with NSCLC treated with RT followed by adjuvant administration of PSK between 1976 and 1989 were analyzed. Of these patients, 170 (76%) had squamous cell carcinoma. In the patients with squamous cell carcinoma of the lung, PSK was given only when the tumor showed satisfactory shrinkage (complete or partial response) after completion of RT. The treatment outcomes were compared with those of the responders to RT not receiving PSK. The 5-year survival rates of patients with stages I-II and stage III disease were 39 and 26%, respectively, while the non-administered responder group’s were 17 and 8%. These differences are statistically significant. An improvement in the treatment results with combined use of appropriate immuno-modulating drugs is anticipated in the future. When clinical trials of the efficacy of these drugs are conducted, the agents should be given to the patients with satisfactory tumor regression after RT, although they still take much time and cost.[…]

The immunomodulator PSK induces in vitro cytotoxic activity in tumor cell lines via arrest of cell cycle and induction of apoptosis

These results indicate that PSK has cytotoxic activity in vitro on tumor cell lines. This new cytotoxic activity of PSK on tumour cells is independent of its previously described immunomodulatory activity on NK cells.[…]

Antimetastatic Effects of PSK (Krestin), a Protein-bound Polysaccharide Obtained from Basidiomycetes: An Overview

PSK is currently used as an immuno therapeutic agent for gastric colorectal, and lung cancers in Japan. It has virtually no adverse effects, and it can be administered P. over a long term. Consequently, its use need not be limited to the treatment of Cancer, and, as our previous paper suggested, it should in the future prove valuable as a general chemopreventive agent and, as this review shows, as anti metastatic agent. The principal mechanisms of PSK may act as an inhibitor of the motility, invasion, and progression of tumor cells, in addition to its role as an immunomodulator.[…]

Coriolus versicolor extracts: relevance in cancer management

The existing evidence on C. versicolor extracts is positive. The role of PSK as a BRM in cancer therapy is well established in Japan, and preliminary research on PSP is promising. Communities in North America are becoming more globally diverse and multicultural.[…]

Yun zhi (Cloud Mushroom) PSP Extract- West Nile Virus and Yun zhi PSP

Yun zhi polysaccharides have been used in the treatment of cancer and hepatitis in China and Japan for years. Patients who have used natural Yun zhi report increased strength and well-being, increased resistance to colds, flu, reduced fatigue and nausea, as well as regaining a normal appetite. Boosting the immune system through the regular use of natural Yun zhi could therefore provide increased protection against the threat of the West Nile Virus.{…}

THE HISTORY OF YUN ZHI PSP (Polysaccharide Peptide) & China Herbals International.

Inclusion in Cereals, Pet foods, Cold drinks, Pasta sauce, Stand-alone single packs in Liquor Stores, Bars and Restaurants for hangovers (gone in 20-30 minutes). Contact: Harry Tosado – 1-877-2-PSPTEA – or go to PSPTEA.COM & download a flyer. Read the testimonials and what doctors have to say about PSP. More data coming soon….[…]