Effect of immunostimulants and antitumor agents on tumor necrosis factor (TNF) production.

Mori H, Mihara M, Teshima K, Uesugi U, Xu Q, Sakamoto O, Koda A.

Department of Pharmacology, Gifu Pharmaceutical University, Japan.

Abstract

OK-432, a lyophilized preparation of Streptococcus pyogenes, showed a priming activity for TNF production in mice, associated with an increase of spleen weight. PSK, a protein-bound polysaccharide preparation from Coriolus versicolor, did not show such activity. Both OK-432 and PSK potentiated the TNF production in mice primed with Corynebacterium parvum (CP) and challenged with Escherichia coli endotoxin (LPS). Cytotoxic antitumor agents of 5-fluorouracil (5-FU), cyclophosphamide (CY) and bleomycin (BLM) suppressed TNF production in mice primed with CP and challenged with LPS. TNF production suppressed by 5-FU, CY and BLM was partially restored by the combined treatment with OK-432 or PSK. These results suggest that the administration of cytotoxic antitumor agents suppresses the intrinsic TNF production in cancer patients, and the combined use of immunostimulants such as OK-432 and PSK is advantageous in restoring TNF production suppressed by cytotoxic antitumor agents.

PMID: 2448255 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/2448255

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