Immune enhancement of a polysaccharides peptides isolated from Coriolus versicolor.

Li XY, Wang JF, Zhu PP, Liu L, Ge JB, Yang SX.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences.

Abstract

A protein-bound polysaccharides (PSP) isolated from Coriolus versicolor in Shanghai, at the concentrations of 100-800 micrograms/ml promoted lymphocyte proliferation. PSP 25 mg/kg ip into mice for 5 d antagonized the inhibition of IL-2 production by cyclophosphamide from activated T lymphocytes and restored the suppressed T-cell-mediated delayed, type hypersensitivity response to normal. PSP 10-1000 micrograms/ml induced interferon alpha and gamma production from human peripheral leukocytes 4 and 8 times respectively higher than that of the control groups. Moreover, PSP also increased phagocytic functions of host reticulo-endothelial system. The results suggest that the anti-tumor effects of PSP may be related to its potentiation of host immunological responses.

PMID: 1718146 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/1718146

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