Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides.

Gong S, Zhang HQ, Yin WP, Yin QZ, Zhang Y, Gu ZL, Qian ZM, Tang PL.

Laboratory of Neurobiology, Suzhou Medical College, China.

Abstract

AIM: To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP).

METHODS: The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.

RESULTS: PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH.

CONCLUSION: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.

PMID: 10375763 [PubMed – indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/10375763

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